Article

The Proteolytic Activation of Vascular Endothelial Growth Factors

2021-01-18

Abstract excerpt

Specific proteolytic cleavages turn on, modify, or turn off the activity of vascular endothelial growth factors (VEGFs). Proteolysis is most prominent among the lymphangiogenic VEGF-C and VEGF-D, which are synthesized as precursors that need to undergo enzymatic removal of their C- and N-terminal propeptides before they can activate their receptors. The activating cleavage of VEGF-C is mediated by at least fi...

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Literature Corpus work: 18ea22c2-8f85-5226-8752-a30b3495db2a
DOI: 10.20944/preprints202101.0304.v1

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