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Article

Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression?

Nature clinical practice. Endocrinology & metabolism - 1 Feb 2007

de Kloet E Ronald, Derijk Roel H, Meijer Onno C

Abstract excerpt

In severely depressed patients, emotional arousal, cognitive abnormality and vulnerability to psychotic episodes are linked to a hyperactive hypothalamic-pituitary-adrenal (HPA) axis and high levels of circulating cortisol. The susceptibility pathways underlying these disturbed brain functions are influenced by genetic factors, early-life priming experiences and later-life events. Cortisol is an important...

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Identifiers

PMID: 17237843
DOI: 10.1038/ncpendmet0403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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