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Article

Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.

Molecular cancer therapeutics - 1 Jan 2007

Sarthy Aparna V, Morgan-Lappe Susan E, Zakula Dorothy, Vernetti Lawrence, Schurdak Mark, Packer Jeremy C L, Anderson Mark G, Shirasawa Senji, Sasazuki Takehiko, Fesik Stephen W

Abstract excerpt

To identify cancer-specific targets, we have conducted a synthetic lethal screen using a small interfering RNA (siRNA) library targeting approximately 4,000 individual genes for enhanced killing in the DLD-1 colon carcinoma cell line that expresses an activated copy of the K-Ras oncogene. We foun...

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Source

Identifiers

PMID: 17237286
DOI: 10.1158/1535-7163.MCT-06-0560

Genes

DLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17237286-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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