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Article

Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy.

Molecular cancer research : MCR - 1 Jul 2005

Fleming Jason B, Shen Guo-Liang, Holloway Shane E, Davis Mishel, Brekken Rolf A

Abstract excerpt

Mutation of the K-ras gene is an early event in the development of pancreatic adenocarcinoma and, therefore, RNA interference (RNAi) directed toward mutant K-ras could represent a novel therapy. In this study, we examine the phenotypic and molecular consequences of exposure of pancreatic tumor cells to mutant-specific K-ras small interfering RNA. Specific reduction of activated K-ras via RNAi in Panc-1 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16046552
DOI: 10.1158/1541-7786.MCR-04-0206

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