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Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

5 May 2003

Abstract excerpt

Elevated expression of mammalian polo-like kinase (Plk)1 occurs in many different types of cancers, and Plk1 has been proposed as a novel diagnostic marker for several tumors. We used the recently developed vector-based small interfering RNA technique to specifically deplete Plk1 in cancer cells. We found that Plk1 depletion dramatically inhibited cell proliferation, decreased viability, and resulted in...

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PMID: 12732729
DOI: 10.1073/pnas.1031523100

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