Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting inhibition of K-ras enhances Ad.mda-7-induced growth suppression and apoptosis in mutant K-ras colorectal cancer cells.

Oncogene - 1 Feb 2007

Lebedeva I V, Su Z-Z, Emdad L, Kolomeyer A, Sarkar D, Kitada S, Waxman S, Reed J C, Fisher P B

Abstract excerpt

Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) is a cancer-specific, growth-suppressing and apoptosis-inducing gene with broad-spectrum antitumor activity. However, when administered by means of a replication-incompetent adenovirus, Ad.mda-7, several colorectal carcinoma cell lines are resistant to its antiproliferative and antisurvival effects. We have presently endeavored to determine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Adjuvants, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to bcl-2-Associated X Protein

Share to bcl-X Protein

Share to Interleukins

Share to Necrosis

Share to Proto-Oncogene Proteins c-bcl-2

Share to Transduction, Genetic

Source

Identifiers

PMID: 16924242
DOI: 10.1038/sj.onc.1209813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting inhibition of K-ras enhances Ad.mda-7-induced growth suppression and apoptosis in mutant K-ras colorectal cancer cells.PMID 16924242Read ↗

Melanoma differentiation associated gene-7 (mda-7)/IL-24: a ‘magic bullet’ for cancer therapy?Semantic proximity Read ↗

Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.Semantic proximity Read ↗

Is <i>mda-7/IL-24</i> a “Magic Bullet” for Cancer?Semantic proximity Read ↗

MDA-7/IL-24 as a cancer therapeutic: from bench to bedsideSemantic proximity Read ↗

Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24Semantic proximity Read ↗

A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.Semantic proximity Read ↗

<i>mda-</i> 7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPKSemantic proximity Read ↗

Potent Antitumor Activity of Oncolytic Adenovirus Expressing mda-7/IL-24 for Colorectal CancerSemantic proximity Read ↗

Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy.Semantic proximity Read ↗

Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.Semantic proximity Read ↗

Melanoma Differentiation Associated Gene-7/Interleukin-24 Promotes Tumor Cell-Specific Apoptosis through Both Secretory and Nonsecretory PathwaysSemantic proximity Read ↗

Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.