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Article

Small interfering RNA targeting survivin sensitizes lung cancer cell with mutant p53 to adriamycin.

International journal of cancer - 15 Feb 2006

Yonesaka Kimio, Tamura Kenji, Kurata Takayasu, Satoh Taroh, Ikeda Masato, Fukuoka Masahiro, Nakagawa Kazuhiko

Abstract excerpt

Survivin is a member of the inhibitor of apoptosis protein (IAP) family that is specifically overexpressed in cancer tissues. p53 is one of the tumor suppressor genes; its induction in response to DNA damage causes apoptosis and correlates with drug sensitivity. To investigate the possible regulation of survivin by p53, we examined the level of survivin expression in lung cancer cell lines in response to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16108013
DOI: 10.1002/ijc.21350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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