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Identification and functional assessment of BCRP polymorphisms in a Korean population.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2007

Lee Sang Seop, Jeong Hye-Eun, Yi Joo-Mi, Jung Hyun-Ju, Jang Jae-Eun, Kim Eun-Young, Lee Su-Jun, Shin Jae-Gook

Abstract excerpt

The breast cancer resistance protein (BCRP) is a member of the ATP-binding cassette transporters. The aim of the present study was to identify genetic variants of BCRP in Koreans and to assess the functional consequences of BCRP polymorphisms. Twenty single nucleotide polymorphisms (SNP), including four nonsynonymous SNP, were identified by DNA sequencing of the BCRP gene in 92 Korean subjects. BCRP V12M, Q141K,...

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ATP Binding Cassette Transporter, Subfamily G, Member 2
Estrone
In Vitro Techniques
Insecta
Korea

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17237154
DOI: 10.1124/dmd.106.012302

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