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Article

Functional SNPs of the breast cancer resistance protein-therapeutic effects and inhibitor development.

Cancer letters - 8 Mar 2006

Yanase Kae, Tsukahara Satomi, Mitsuhashi Junko, Sugimoto Yoshikazu

Abstract excerpt

Breast cancer resistance protein (BCRP) is a half-molecule ATP-binding cassette transporter that pumps out various anticancer agents such as 7-ethyl-10-hydroxycamptothecin, topotecan and mitoxantrone. We have previously identified three polymorphisms within the BCRP gene, G34A (substituting Met for Val-12), C376T (substituting a stop codon for Gln-126) and C421A (substituting Lys for Gln-141). C421A...

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Antineoplastic Agents
ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters
Breast Neoplasms
Drug Resistance, Multiple

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Proteins

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 16303243
DOI: 10.1016/j.canlet.2005.04.039

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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