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Article

Functional analysis of the human variants of breast cancer resistance protein: I206L, N590Y, and D620N.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jun 2005

Vethanayagam R Robert, Wang Honggang, Gupta Anshul, Zhang Yi, Lewis Fred, Unadkat Jashvant D, Mao Qingcheng

Abstract excerpt

Previous studies have shown that the V12M and Q141K variants of breast cancer resistance protein (BCRP) can affect expression and function of the transporter. In this study, the effects of the I206L, N590Y, and D620N variants on protein expression, plasma membrane localization, and transport activity of BCRP were investigated. Wild-type BCRP and the three variants were stably expressed in human embryonic kidney...

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PMID: 15743976
DOI: 10.1124/dmd.105.003657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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