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Article

Functional analysis of genetic variations in the 5'-flanking region of the human MDR1 gene.

Molecular genetics and metabolism - 1 Jan 2011

Saeki Mayumi, Kurose Kouichi, Hasegawa Ryuichi, Tohkin Masahiro

Abstract excerpt

P-glycoprotein (P-gp), the product of the MDR1 gene, shows large interindividual variations in expression, which leads to differences in the pharmacokinetics of the substrate drugs. The functions of single nucleotide polymorphisms located in the nuclear receptor-responsive element of the 5'-flanking region in the human MDR1 gene were analyzed in order to clarify the mechanism underlying the interindividual...

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PMID: 20855224
DOI: 10.1016/j.ymgme.2010.08.019

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VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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