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Ethnic Bridging of Sepiapterin in Chinese and Korean Populations Based on Predictions From Genetic Polymorphism of Breast Cancer Resistance Protein.

Clinical and translational science - 1 Apr 2026

Gao Lan, Smith Neil, Kong Ronald

Abstract excerpt

Ethnic differences are crucial when considering the efficacy, safety, and dose of pharmaceuticals across diverse populations. The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guideline E5 addresses the acceptability of extrapolating foreign clinical data taking ethnic factors into consideration. Sepiapterin has recently been approved for the treatment...

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Asian People
ATP Binding Cassette Transporter, Subfamily G, Member 2
Biopterins
East Asian People
Neoplasm Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenylketonurias

Republic of Korea

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PMID: 41995148
DOI: 10.1111/cts.70549
PMCID: PMC13088331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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