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Article

Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy.

Advanced drug delivery reviews - 31 Jan 2009

Noguchi Kohji, Katayama Kazuhiro, Mitsuhashi Junko, Sugimoto Yoshikazu

Abstract excerpt

The breast cancer resistance protein, BCRP/ABCG2, is a half-molecule ATP-binding cassette transporter that facilitates the efflux of various anticancer agents from the cell, including 7-ethyl-10-hydroxycamptothecin, topotecan and mitoxantrone. The expression of BCRP can thus confer a multidrug resistance phenotype in cancer cells, and its transporter activity is involved in the in vivo efficacy of...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19111841
DOI: 10.1016/j.addr.2008.07.003

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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