Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent manner.

The Journal of biological chemistry - 16 Mar 2007

Altenburg Michael, Johnson Lance, Wilder Jennifer, Maeda Nobuyo

Abstract excerpt

Apolipoprotein E (apoE) and the low density lipoprotein receptor (LDLr) are well recognized determinants of atherosclerosis. In addition to hepatocytes, where both are highly expressed and contribute to plasma lipoprotein clearance, they are expressed in vascular cells and macrophages. In this study, we examined the effects of human apoE isoforms and LDLr levels in atherogenic pathways in primary macrophages ex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bone Marrow Cells

Share to Bone Marrow Transplantation

Share to Cholesterol

Share to Hepatocytes

Share to Protein Isoforms

Share to Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 17234631
DOI: 10.1074/jbc.M610712200
PMCID: PMC5278600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent manner.PMID 17234631Read ↗

Evidence for differential effects of apoE3 and apoE4 on HDL metabolism.Semantic proximity Read ↗

Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptor.Semantic proximity Read ↗

Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice.Semantic proximity Read ↗

Macrophages, lipoprotein metabolism, and atherosclerosisSemantic proximity Read ↗

ApoE knockout and knockin mice: the history of their contribution to the understanding of atherogenesisSemantic proximity Read ↗

Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of InflammationSemantic proximity Read ↗

Liver-directed gene transfer and prolonged expression of three major human ApoE isoforms in ApoE-deficient mice.Semantic proximity Read ↗

Do the Apoe-/- and Ldlr-/- Mice Yield the Same Insight on Atherogenesis?Semantic proximity Read ↗

Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice.Semantic proximity Read ↗

Genetic variants of ApoE and ApoER2 differentially modulate endothelial functionSemantic proximity Read ↗

Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis.Semantic proximity Read ↗

Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.