Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages.

doi:10.1172/JCI119887

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Article

Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages.

The Journal of clinical investigation - 15 Apr 1998

Cullen P, Cignarella A, Brennhausen B, Mohr S, Assmann G, von Eckardstein A

Abstract excerpt

In this study, we investigated the impact of the common apoE polymorphism on apoE metabolism and cholesterol homeostasis in monocyte-derived macrophages isolated from E2/2, E3/3, and E4/4 subjects. Unloaded cells of all genotypes contained similar amounts of free cholesterol, cholesteryl ester, a...

Topics

Adult
Alzheimer Disease
Apolipoproteins E
Arteriosclerosis
Cholesterol
Cholesterol Esters
Female
Foam Cells
Gene Expression
Heparin Lyase
Homeostasis
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Vitro Techniques

Macrophages

Male

Middle Aged

Monocytes

Phenotype

Source

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Identifiers

PMID: 9541497
DOI: 10.1172/JCI119887
PMCID: PMC508748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9541497-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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