Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2008

Altenburg Michael, Arbones-Mainar Jose, Johnson Lance, Wilder Jennifer, Maeda Nobuyo

Abstract excerpt

OBJECTIVE: In humans, apolipoprotein (apo) E4 is associated with elevated plasma cholesterol levels and a high risk of developing atherosclerosis, whereas apoE2 is protective. Here we investigate the mechanism by which mice expressing human apoE isoforms recapitulate this association when they also express high levels of human low-density lipoprotein receptor (LDLR). METHODS AND RESULTS: Primary hepatocytes from...

Topics

Adenoviridae
Alleles
Animals
Apolipoprotein E2
Apolipoprotein E3
Apolipoprotein E4
Cells, Cultured
Cholesterol, VLDL
Hepatocytes
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Knockout

Protein Isoforms

Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 18369154
DOI: 10.1161/ATVBAHA.108.164863
PMCID: PMC5268126

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice.PMID 18369154Read ↗

Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent manner.Semantic proximity Read ↗

Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptor.Semantic proximity Read ↗

LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice.Semantic proximity Read ↗

Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation.Semantic proximity Read ↗

Liver-directed gene transfer and prolonged expression of three major human ApoE isoforms in ApoE-deficient mice.Semantic proximity Read ↗

The Extent to Which Lipid Nanoparticles Require Apolipoprotein E and Low-Density Lipoprotein Receptor for Delivery Changes with Ionizable Lipid StructureSemantic proximity Read ↗

Endosomal egress and intercellular transmission of hepatic ApoE-containing lipoproteins and its exploitation by the hepatitis C virusSemantic proximity Read ↗

Differences in Recycling of Apolipoprotein E3 and E4-LDL Receptor Complexes-A Mechanistic Hypothesis.Semantic proximity Read ↗

Mechanisms of hepatic chylomicron remnant clearance.Semantic proximity Read ↗

The Role of Impaired Receptor Trafficking in Mediating the Pathological Effects of ApoE4 in Alzheimer DiseaseSemantic proximity Read ↗

Recycling of Apolipoprotein E and Lipoprotein Lipase through Endosomal Compartments in VivoSemantic proximity Read ↗

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion <i>in vitro</i> and in mouse liverSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.