Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3.

Journal of neurochemistry - 1 Dec 2006

Clark Mary J, Traynor John R

Abstract excerpt

Chronic activation of mu-opioid receptors, which couple to pertussis toxin-sensitive Galphai/o proteins to inhibit adenylyl cyclase (AC), leads to a compensatory sensitization of AC. Pertussis toxin-insensitive mutations of Galphai/o subtypes, in which the pertussis toxin-sensitive cysteine is mutated to isoleucine (Galpha ), were used to determine whether each of the Galphai/o subtypes is able to mediate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 1-Methyl-3-isobutylxanthine
Share to Adenylyl Cyclases
Share to Analgesics, Opioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colforsin

Share to GTP-Binding Protein alpha Subunits, Gi-Go

Share to Pertussis Toxin

Share to Phosphodiesterase Inhibitors

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 17230639
DOI: 10.1111/j.1471-4159.2006.04176.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3.PMID 17230639Read ↗

Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation.Semantic proximity Read ↗

Sensitization of the adenylyl cyclase system in cloned kappa-opioid receptor-transfected cells following sustained agonist treatment: A chimeric study using G protein alpha(i)2/alpha(q) subunits.Semantic proximity Read ↗

Go G-proteins mediate rapid heterologous desensitization of G-protein coupled receptors in Xenopus oocytes.Semantic proximity Read ↗

Dopamine D2 receptor-induced heterologous sensitization of adenylyl cyclase requires Galphas: characterization of Galphas-insensitive mutants of adenylyl cyclase V.Semantic proximity Read ↗

Preactivation permits subsequent stimulation of phospholipase C by G(i)-coupled receptors.Semantic proximity Read ↗

Pertussis toxin-sensitive signaling of melanocortin-4 receptors in hypothalamic GT1-7 cells defines agouti-related protein as a biased agonist.Semantic proximity Read ↗

Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase.Semantic proximity Read ↗

Ser/ Thr residues at α3/β5 loop of Gαs are important in morphine-induced adenylyl cyclase sensitization but not mitogen-activated protein kinase phosphorylation.Semantic proximity Read ↗

Closely related G-protein-coupled receptors use multiple and distinct domains on G-protein alpha-subunits for selective coupling.Semantic proximity Read ↗

Chimeras of the Gs alpha subunit that had the NH2- or COOH-terminal sequence substituted for the corresponding region of the Gi alpha subunit constitutively activate adenylyl cyclase.Semantic proximity Read ↗

Multiple pertussis toxin-sensitive G-proteins can couple receptors to GIRK channels in rat sympathetic neurons when expressed heterologously, but only native G(i)-proteins do so in situ.Semantic proximity Read ↗

Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.