Article
Ser/ Thr residues at α3/β5 loop of Gαs are important in morphine-induced adenylyl cyclase sensitization but not mitogen-activated protein kinase phosphorylation.
The FEBS journal - 1 Feb 2012
Seyedabadi Mohammad, Ostad Seyed Nasser, Albert Paul R, Dehpour Ahmad R, Rahimian Reza, Ghazi-Khansari Mahmoud, Ghahremani Mohammad H
Abstract excerpt
The signaling switch of β2-adrenergic and μ(1) -opioid receptors from stimulatory G-protein (G(αs) ) to inhibitory G-protein (G(αi) ) (and vice versa) influences adenylyl cyclase (AC) and extracellular-regulated kinase (ERK)1/2 activation. Post-translational modifications, including dephosphorylation of G(αs) , enhance opioid receptor coupling to G(αs) . In the present study, we substituted the Ser/Thr residues...
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