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Article

Pertussis toxin-sensitive signaling of melanocortin-4 receptors in hypothalamic GT1-7 cells defines agouti-related protein as a biased agonist.

The Journal of biological chemistry - 25 Sept 2009

Büch Thomas R H, Heling Dominik, Damm Ellen, Gudermann Thomas, Breit Andreas

Abstract excerpt

Melanocortin-4 receptor (MC4R)-induced anorexigenic signaling in the hypothalamus controls body weight and energy homeostasis. So far, MC4R-induced signaling has been exclusively attributed to its coupling to G(s) proteins. In line with this monogamous G protein coupling profile, most MC4R mutants isolated from obese individuals showed a reduced ability to activate G(s). However, some mutants displayed enhanced...

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Share to Agouti-Related Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gi-Go

Share to Guanosine 5'-O-(3-Thiotriphosphate)

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Share to Receptor, Melanocortin, Type 4

Source

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Identifiers

PMID: 19648111
DOI: 10.1074/jbc.M109.039339
PMCID: PMC2785329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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