Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation.

The Journal of pharmacology and experimental therapeutics - 1 May 2006

Clark Mary J, Furman Cheryse A, Gilson Timra D, Traynor John R

Abstract excerpt

Pertussis toxin (PTX)-insensitive mutants of Galpha(i/o) proteins expressed in C6mu cells were used to examine the hypothesis that there are agonist-specific conformational states of the mu-opioid receptor with coupling preferences to different Galpha(i/o) subtypes, as measured by the degree of stimulation of [(35)S]guanosine 5'-O-(3-thio)triphosphate (GTPgammaS) binding. Binding of [(35)S]GTPgammaS to endogenous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gi-Go

Share to Mutation

Share to Pertussis Toxin

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 16436499
DOI: 10.1124/jpet.105.096818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation.PMID 16436499Read ↗

Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3.Semantic proximity Read ↗

Pertussis toxin-sensitive signaling of melanocortin-4 receptors in hypothalamic GT1-7 cells defines agouti-related protein as a biased agonist.Semantic proximity Read ↗

Closely related G-protein-coupled receptors use multiple and distinct domains on G-protein alpha-subunits for selective coupling.Semantic proximity Read ↗

Comparison of G-protein activation in the brain by mu-, delta-, and kappa-opioid receptor agonists in mu-opioid receptor knockout mice.Semantic proximity Read ↗

Go G-proteins mediate rapid heterologous desensitization of G-protein coupled receptors in Xenopus oocytes.Semantic proximity Read ↗

Effects of C-terminal truncation of the recombinant delta-opioid receptor on phospholipase C and adenylyl cyclase coupling.Semantic proximity Read ↗

Preactivation permits subsequent stimulation of phospholipase C by G(i)-coupled receptors.Semantic proximity Read ↗

Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction.Semantic proximity Read ↗

Differential G protein activation by fusion proteins between the human δ-opioid receptor and Gᵢ₁α/G₀₁α proteinsSemantic proximity Read ↗

Quantitative evaluation of human delta opioid receptor desensitization using the operational model of drug action.Semantic proximity Read ↗

Functional analysis of MOR-1 splice variants of the mouse mu opioid receptor gene Oprm.Semantic proximity Read ↗

Role for the C-terminus in agonist-induced mu opioid receptor phosphorylation and desensitization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.