Article
Endometrial cancer risk is associated with variants of the mismatch repair genes MLH1 and MSH2.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2006
Beiner Mario E, Rosen Barry, Fyles Anthony, Harley Ian, Pal Tuya, Siminovitch Kathy, Zhang Shiyu, Sun Ping, Narod Steven A
Abstract excerpt
Women with germ-line mutations in the mismatch repair genes (responsible for hereditary nonpolyposis colorectal cancer) face an increased risk of colonic and endometrial cancer. However, these germ-line mutations are rare and are responsible for fewer than 1% of endometrial cancers. Therefore, we examined whether or not common variants of the hereditary nonpolyposis colorectal cancer-associated genes might also...
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