Convergent extension analysis in mouse whole embryo culture.

doi:10.1007/978-1-61779-510-7_11

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Article

Convergent extension analysis in mouse whole embryo culture.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Pryor Sophie E, Massa Valentina, Savery Dawn, Greene Nicholas D E, Copp Andrew J

Abstract excerpt

Mutations have been identified in a non-canonical Wnt signalling cascade (the planar cell polarity pathway) in several mouse genetic models of severe neural tube defects. In each of these models, neurulation fails to be initiated at the 3-4 somite stage, leading to an almost entirely open neural tube (termed craniorachischisis). Studies in whole embryo culture have identified a defect in the morphogenetic process...

Topics

Animals
Carbocyanines
Cell Polarity
Dissection
Electroporation
Embryo Culture Techniques
Embryo, Mammalian
Female
Genetic Vectors
Green Fluorescent Proteins
Mice
Mutation
Nerve Tissue Proteins
Neural Plate
Neural Tube
Neurulation
Paraffin Embedding
Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 22218898
DOI: 10.1007/978-1-61779-510-7_11
PMCID: PMC3616368

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