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Article

In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais.

Drug metabolism and pharmacokinetics - 1 Dec 2006

Peamkrasatam Sompop, Sriwatanakul Kampon, Kiyotani Kazuma, Fujieda Masaki, Yamazaki Hiroshi, Kamataki Tetsuya, Yoovathaworn Krongtong

Abstract excerpt

The association between the distribution characteristics of CYP2A6 catalytic activities toward nicotine and coumarin, and the frequency distribution of CYP2A6 variant alleles reported was estimated in 120 healthy Thais. The distributions of the subjects as classified by the amounts of 7-hydroxycoumarin (7-OHC) excreted in the urine and by cotinine/nicotine ratio in the plasma were clearly bimodal. However, the...

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PMID: 17220563
DOI: 10.2133/dmpk.21.475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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