Article
Haplotype-based analysis of common variation in the growth hormone receptor gene and prostate cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2007
McKay James D, Kaaks Rudolf, Johansson Mattias, Biessy Carine, Wiklund Fredik, Bälter Katarina, Adami Hans-Olov, Boillot Catherine, Gioia-Patricola Lydie, Canzian Federico, Stattin Pär, Grönberg Henrik
Abstract excerpt
The growth hormone receptor (GHR) is potentially involved in prostate cancer through its role in stimulating insulin-like growth factor I production and its cellular effects on prostate epithelium. We have used a haplotype-based tagging approach within CAncer Prostate Sweden, a large retrospective case-control study of 2,863 cases and 1,737 controls to investigate if genetic variation in the GHR gene influences...
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