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Article

Polymorphisms in the growth hormone receptor: a case-control study in breast cancer.

International journal of cancer - 1 Jun 2006

Wagner Kerstin, Hemminki Kari, Grzybowska Ewa, Bermejo Justo Lorenzo, Butkiewicz Dorota, Pamula Jolanta, Pekala Wioletta, Försti Asta

Abstract excerpt

The human growth hormone receptor (GHR) mediates the effects of growth hormone (GH1), starting a signalling cascade that is involved in the regulation of proliferation, differentiation and apoptosis. Recently, an isoform of the GHR gene lacking exon 3 (GHRd3) was associated with accelerated responsiveness to growth hormone. In this study, we investigated the association of the GHRd3 polymorphism with breast...

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Identifiers

PMID: 16381017
DOI: 10.1002/ijc.21703

Genes

GHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in the growth hormone receptor: a case-control study in breast cancer.PMID 16381017Read ↗

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Genetic polymorphisms in the human growth hormone-1 gene (GH1) and the risk of breast carcinoma.Semantic proximity Read ↗

The prevalence of polymorphism of exon 3 expression of the growth hormone receptor gene in the general population and its influence on quality of life, body composition and response to growth hormone replacement in growth hormone deficient adultsSemantic proximity Read ↗

The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature.Semantic proximity Read ↗

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