Article
Haplotype analysis of the growth hormone releasing hormone receptor locus in three apparently unrelated kindreds from the indian subcontinent with the identical mutation in the GHRH receptor.
American journal of medical genetics. Part A - 1 Jul 2003
Wajnrajch Michael P, Gertner Joseph M, Sokoloff Alisa S, Ten Irina, Harbison Madeleine D, Netchine Irène, Maheshwari Hiralal G, Goldstein David B, Amselem Serge, Baumann Gerhard, Leibel Rudolph L
Abstract excerpt
The growth hormone releasing hormone receptor (GHRHR) plays a critical role in growth. We identified three nominally unrelated kindreds harboring the identical mutation (E72X) in GHRHR, the gene that encodes GHRHR; all three families originated in the Indian subcontinent. Because of the relative geographic proximity of these populations, we employed haplotype analysis in the region of GHRHR to determine the...
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