Article
Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
European journal of cancer (Oxford, England : 1990) - 1 Feb 2011
Campa Daniele, Hüsing Anika, Chang-Claude Jenny, Dostal Lucie, Boeing Heiner, Kröger Janine, Tjønneland Anne, Roswall Nina, Overvad Kim, Dahm Christina C, Rodríguez Laudina, Sala Núria, Pérez Maria José Sánchez, Larrañaga Nerea, Chirlaque Maria-Dolores, Ardanaz Eva, Khaw Kay-Tee, Wareham Nick, Allen Naomi E, Travis Ruth C, Trichopoulou Antonia, Naska Androniki, Bamia Christina, Palli Domenico, Sieri Sabina, Tumino Rosario, Sacerdote Carlotta, van Kranen Henk J, Bas Bueno-de-Mesquita H, Stattin Pär, Johansson Mattias, Chajes Veronique, Rinaldi Sabina, Romieu Isabelle, Siddiq Afshan, Norat Teresa, Riboli Elio, Kaaks Rudolf, Canzian Federico
Abstract excerpt
A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes...
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