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Article

The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and tumor risk: evidence from 134 case-control studies.

Molecular biology reports - 1 Jul 2014

Tang Min, Wang Shang-Qian, Liu Bian-Jiang, Cao Qiang, Li Bing-Jie, Li Peng-Chao, Li Yong-Fei, Qin Chao, Zhang Wei

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, which is essential for DNA synthesis and methylation. Genetic variations in the MTHFR gene seem to contribute to a decreased activity of MTHFR, ultimately confer increased susceptibility to cancer. As the most extensively studied polymorphism, MTHFR C677T polymorphism was shown to contribute to cancer susceptibility...

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PMID: 24744129
DOI: 10.1007/s11033-014-3337-9

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MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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