Article
The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus.
Journal of medical genetics - 1 May 2007
Hellquist Anna, Zucchelli Marco, Kivinen Katja, Saarialho-Kere Ulpu, Koskenmies Sari, Widen Elisabeth, Julkunen Heikki, Wong Andrew, Karjalainen-Lindsberg Marja-Liisa, Skoog Tiina, Vendelin Johanna, Cunninghame-Graham Deborah S, Vyse Timothy J, Kere Juha, Lindgren Cecilia M
Abstract excerpt
BACKGROUND: Several members of the GIMAP gene family have been suggested as being involved in different aspects of the immune system in different species. Recently, a mutation in the GIMAP5 gene was shown to cause lymphopenia in a rat model of autoimmune insulin-dependent diabetes. Thus it was hypothesised that genetic variation in GIMAP5 may be involved in susceptibility to other autoimmune disorders where...
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