Article
IAN5 polymorphisms are associated with systemic lupus erythematosus.
Lupus - 1 Oct 2009
Lim M K, Sheen D H, Kim S A, Won S K, Lee S-S, Chae S-C, Chung H-T, Shim S C
Abstract excerpt
Systemic lupus erythematosus (SLE) is a representative autoimmune disease, which is frequently associated with lymphopenia. Biobreeding (BB) rat is a typical animal model which develops autoimmune diseases with lymphopenia which results from a frame-shift mutation in the immune-associated nucleotide (IAN) 5 gene. IAN5 is involved in the regulation of T-cell activation and survival. To examine the association of...
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