Article
Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population.
Annals of the rheumatic diseases - 1 Jul 2011
Zhou Xu-jie, Lu Xiao-lan, Lv Ji-cheng, Yang Hai-zhen, Qin Lian-xiang, Zhao Ming-hui, Su Yin, Li Zhan-guo, Zhang Hong
Abstract excerpt
OBJECTIVE: Recent genome-wide association studies suggested the PRDM1-ATG5 gene region as a systemic lupus erythematosus (SLE)-associated locus both in Caucasian and Chinese populations; however, the candidate gene was still obscure and the possible functional significance needed to be determined. METHODS: In this study, by a multistage integrative strategy, the authors first performed a case-control association...
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