Article
The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells.
Apoptosis : an international journal on programmed cell death - 1 Mar 2007
Hung Hui-Chih, Lin Chien-Yu, Liao Ya-Fan, Hsu Pei-Chen, Tsay Gregory J, Liu Guang-Yaw
Abstract excerpt
Peptidylarginine deiminase IV (PADI4) posttranslationally converts peptidylarginine to citrulline. It plays an essential role in immune cell differentiation and apoptosis. A haplotype of single-nucleotide polymorphisms (SNPs) in PADI4 is functionally relevant as a rheumatoid arthritis (RA) gene....
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