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Article

Implications of Peptidyl Arginine Deiminase 4 gene transcription and polymorphisms in susceptibility to rheumatoid arthritis in an Iranian population.

BMC medical genomics - 16 May 2023

Bagheri-Hosseinabadi Zahra, Mirzaei Mohammad Reza, Esmaeili Ozrasadat, Asadi Fatemeh, Ahmadinia Hassan, Shamsoddini Banafshe, Abbasifard Mitra

Abstract excerpt

BACKGROUND: Peptidyl arginine deiminase 4 (PADI4) has been implicated in Rheumatoid arthritis (RA) pathogenesis. Here we aimed to evaluate the association of PADI4 gene rs11203367 and rs1748033 single nucleotide polymorphisms (SNPs) with RA proneness. METHODS: The mRNA expression of PADI4 was determined in the whole blood samples. The genotyping of PADI4 polymorphisms was conducted using allelic discrimination...

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Share to Arthritis, Rheumatoid
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Identifiers

PMID: 37193992
DOI: 10.1186/s12920-023-01532-9
PMCID: PMC10186752

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