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Article

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.

Nature genetics - 1 Aug 2003

Suzuki Akari, Yamada Ryo, Chang Xiaotian, Tokuhiro Shinya, Sawada Tetsuji, Suzuki Masakatsu, Nagasaki Miyuki, Nakayama-Hamada Makiko, Kawaida Reimi, Ono Mitsuru, Ohtsuki Masahiko, Furukawa Hidehiko, Yoshino Shinichi, Yukioka Masao, Tohma Shigeto, Matsubara Tsukasa, Wakitani Shigeyuki, Teshima Ryota, Nishioka Yuichi, Sekine Akihiro, Iida Aritoshi, Takahashi Atsushi, Tsunoda Tatsuhiko, Nakamura Yusuke, Yamamoto Kazuhiko

Abstract excerpt

Individuals with rheumatoid arthritis frequently have autoantibodies to citrullinated peptides, suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes (encoded by PADI genes) in rheumatoid arthritis. Previous linkage studies have shown that a susceptibility locus for...

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Source

Identifiers

PMID: 12833157
DOI: 10.1038/ng1206

Genes

PADI4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12833157-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.PMID 12833157Read ↗

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