Article
Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.
Development (Cambridge, England) - 1 Feb 2007
Takada Yuki, Isono Kyo-ichi, Shinga Jun, Turner James M A, Kitamura Hiroshi, Ohara Osamu, Watanabe Gen, Singh Prim B, Kamijo Takehiko, Jenuwein Thomas, Burgoyne Paul S, Koseki Haruhiko
Abstract excerpt
The product of the Scmh1 gene, a mammalian homolog of Drosophila Sex comb on midleg, is a constituent of the mammalian Polycomb repressive complexes 1 (Prc1). We have identified Scmh1 as an indispensable component of the Prc1. During progression through pachytene, Scmh1 was shown to be excluded from the XY body at late pachytene, together with other Prc1 components such as Phc1, Phc2, Rnf110 (Pcgf2), Bmi1 and...
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