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Article

Needs and targets for the multi sex combs gene product in Drosophila melanogaster.

Genetics - 1 Aug 1998

Saget O, Forquignon F, Santamaria P, Randsholt N B

Abstract excerpt

We have analyzed the requirements for the multi sex combs (mxc) gene during development to gain further insight into the mechanisms and developmental processes that depend on the important trans-regulators forming the Polycomb group (PcG) in Drosophila melanogaster. mxc is allelic with the tumor suppressor locus lethal (1) malignant blood neoplasm (l(1)mbn). We show that the mxc product is dramatically needed in...

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Identifiers

PMID: 9691040
DOI: 10.1093/genetics/149.4.1823
PMCID: PMC1460259

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Needs and targets for the multi sex combs gene product in Drosophila melanogaster.PMID 9691040Read ↗

Characterization of a region of the X chromosome of Drosophila including multi sex combs (mxc), a Polycomb group gene which also functions as a tumour suppressor.Semantic proximity Read ↗

Persistent replicative stress alters polycomb phenotypes and tissue homeostasis in Drosophila melanogaster.Semantic proximity Read ↗

The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs.Semantic proximity Read ↗

Genetic interactions and dosage effects of Polycomb group genes of Drosophila.Semantic proximity Read ↗

Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.Semantic proximity Read ↗

Transcription-independent function of Polycomb group protein PSC in cell cycle control.Semantic proximity Read ↗

The Polycomb group gene Posterior Sex Combs encodes a chromosomal protein.Semantic proximity Read ↗

The Drosophila Polycomb group gene Sex combs extra encodes the ortholog of mammalian Ring1 proteins.Semantic proximity Read ↗

Screen for enhancers of Polycomb and Polycomblike in Drosophila melanogaster.Semantic proximity Read ↗

The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.Semantic proximity Read ↗

Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia.Semantic proximity Read ↗

Genetic analysis of the additional sex combs locus of Drosophila melanogaster.Semantic proximity Read ↗

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