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Article

Dynamics of Hepatitis B Virus Resistance to Lamivudine

26 Dec 2005

Abstract excerpt

Lamivudine was the first approved inhibitor of hepatitis B virus (HBV) reverse transcriptase (RT). Lamivudine resistance develops in 53% to 76% of patients after 3 years of treatment. We extensively characterized the dynamics of HBV quasispecies variant populations in four HBV-infected patients who developed lamivudine resistance. Virological breakthrough was preceded by 2 to 4 months by the emergence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16378967
DOI: 10.1128/jvi.80.2.643-653.2006

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