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Article

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils.

Journal of molecular biology - 4 Oct 2002

Lashuel Hilal A, Petre Benjamin M, Wall Joseph, Simon Martha, Nowak Richard J, Walz Thomas, Lansbury Peter T

Abstract excerpt

Two mutations in the alpha-synuclein gene (A30P and A53T) have been linked to autosomal dominant early-onset Parkinson's disease (PD). Both mutations promote the formation of transient protofibrils (prefibrillar oligomers), suggesting that protofibrils are linked to cytotoxicity. In this work, the effect of these mutations on the structure of alpha-synuclein oligomers was investigated using electron microscopy...

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PMID: 12367530
DOI: 10.1016/s0022-2836(02)00735-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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