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Article

Detection of minor drug-resistant populations by parallel allele-specific sequencing.

Nature methods - 1 Feb 2007

Cai Fangping, Chen Haifeng, Hicks Charles B, Bartlett John A, Zhu Jun, Gao Feng

Abstract excerpt

We developed a highly sensitive parallel allele-specific sequencing (PASS) assay to simultaneously analyze a large number of viral genomes and detect minor drug-resistant populations at approximately 0.1-0.01% levels. Using this assay on samples from individuals infected with human immunodeficiency viruses (HIV), we successfully detected and quantified minor populations of drug-resistant viruses and performed...

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PMID: 17206150
DOI: 10.1038/nmeth995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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