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Article

Maf1, a New Player in the Regulation of Human RNA Polymerase III Transcription

27 Dec 2006

Abstract excerpt

BACKGROUND: Human RNA polymerase III (pol III) transcription is regulated by several factors, including the tumor suppressors P53 and Rb, and the proto-oncogene c-Myc. In yeast, which lacks these proteins, a central regulator of pol III transcription, called Maf1, has been described. Maf1 is required for repression of pol III transcription in response to several signal transduction pathways and is broadly...

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PMID: 17205138
DOI: 10.1371/journal.pone.0000134

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