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Article

Full repression of RNA polymerase III transcription requires interaction between two domains of its negative regulator Maf1.

The Journal of biological chemistry - 12 Nov 2010

Gajda Anna, Towpik Joanna, Steuerwald Ulrich, Müller Christoph W, Lefebvre Olivier, Boguta Magdalena

Abstract excerpt

Maf1, first identified in yeast Saccharomyces cerevisiae, is a general negative regulator of RNA polymerase III (Pol III). Transcription regulation by Maf1 is important under stress conditions and during the switch between fermentation and respiration. Maf1 is composed of two domains conserved during evolution. We report here that these two domains of human Maf1 are resistant to mild proteolysis and interact...

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Identifiers

PMID: 20817737
DOI: 10.1074/jbc.M110.125286
PMCID: PMC2975196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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