Article
Maf1 is involved in coupling carbon metabolism to RNA polymerase III transcription.
Molecular and cellular biology - 1 Nov 2007
Cieśla Małgorzata, Towpik Joanna, Graczyk Damian, Oficjalska-Pham Danuta, Harismendy Olivier, Suleau Audrey, Balicki Karol, Conesa Christine, Lefebvre Olivier, Boguta Magdalena
Abstract excerpt
RNA polymerase III (Pol III) produces essential components of the biosynthetic machinery, and therefore its activity is tightly coupled with cell growth and metabolism. In the yeast Saccharomyces cerevisiae, Maf1 is the only known global and direct Pol III transcription repressor which mediates numerous stress signals. Here we demonstrate that transcription regulation by Maf1 is not limited to stress but is...
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