Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila.

doi:10.1038/nature05388

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Article

Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila.

Nature - 4 Jan 2007

Haag-Liautard Cathy, Dorris Mark, Maside Xulio, Macaskill Steven, Halligan Daniel L, Houle David, Charlesworth Brian, Keightley Peter D

Abstract excerpt

Spontaneous mutations are the source of genetic variation required for evolutionary change, and are therefore important for many aspects of evolutionary biology. For example, the divergence between taxa at neutrally evolving sites in the genome is proportional to the per nucleotide mutation rate, u (ref. 1), and this can be used to date speciation events by assuming a molecular clock. The overall rate of...

Topics

Animals
Base Sequence
DNA Mutational Analysis
Drosophila melanogaster
Evolution, Molecular
Genome, Insect
Genomics
Genotype
Models, Genetic
Mutagenesis
Mutation
Nucleotides
Polymorphism, Genetic

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PMID: 17203060
DOI: 10.1038/nature05388

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