Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estimate of the mutation rate per nucleotide in humans.

Genetics - 1 Sept 2000

Nachman M W, Crowell S L

Abstract excerpt

Many previous estimates of the mutation rate in humans have relied on screens of visible mutants. We investigated the rate and pattern of mutations at the nucleotide level by comparing pseudogenes in humans and chimpanzees to (i) provide an estimate of the average mutation rate per nucleotide, (ii) assess heterogeneity of mutation rate at different sites and for different types of mutations, (iii) test the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human
Share to DNA
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Pan troglodytes

Share to Pseudogenes

Share to Species Specificity

Share to X Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 10978293
DOI: 10.1093/genetics/156.1.297
PMCID: PMC1461236

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estimate of the mutation rate per nucleotide in humans.PMID 10978293Read ↗

Direct estimates of human per nucleotide mutation rates at 20 loci causing Mendelian diseases.Semantic proximity Read ↗

A molecular approach to estimating the human deleterious mutation rate.Semantic proximity Read ↗

Nonhuman genetics. Strong male bias drives germline mutation in chimpanzees.Semantic proximity Read ↗

Mutational spectrum in the recent human genome inferred by single nucleotide polymorphisms.Semantic proximity Read ↗

Rate, molecular spectrum, and consequences of human mutation.Semantic proximity Read ↗

Mutation rates in mammalian genomes.Semantic proximity Read ↗

Patterns of nucleotide substitution, insertion and deletion in the human genome inferred from pseudogenes.Semantic proximity Read ↗

Genomic mutation rates: what high-throughput methods can tell us.Semantic proximity Read ↗

Direct estimation of de novo mutation rates in a chimpanzee parent-offspring trio by ultra-deep whole genome sequencing.Semantic proximity Read ↗

Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes.Semantic proximity Read ↗

Mutation saturation for fitness effects at human CpG sitesSemantic proximity Read ↗

Estimation of the spontaneous mutation rate per nucleotide site in a Drosophila melanogaster full-sib family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.