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The challenge and promise of estimating the de novo mutation rate from whole-genome comparisons among closely related individuals.

Molecular ecology - 1 Dec 2021

Yoder Anne D, Tiley George P

Abstract excerpt

Germline mutations are the raw material for natural selection, driving species evolution and the generation of earth's biodiversity. Without this driver of genetic diversity, life on earth would stagnate. Yet, it is a double-edged sword. An excess of mutations can have devastating effects on fitness and population viability. It is therefore one of the great challenges of molecular ecology to determine the rate...

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PMID: 34062029
DOI: 10.1111/mec.16007

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