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Article

Deep sequencing of natural and experimental populations of Drosophila melanogaster reveals biases in the spectrum of new mutations.

Genome research - 1 Dec 2017

Assaf Zoe June, Tilk Susanne, Park Jane, Siegal Mark L, Petrov Dmitri A

Abstract excerpt

Mutations provide the raw material of evolution, and thus our ability to study evolution depends fundamentally on having precise measurements of mutational rates and patterns. We generate a data set for this purpose using (1) de novo mutations from mutation accumulation experiments and (2) extremely rare polymorphisms from natural populations. The first, mutation accumulation (MA) lines are the product of...

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Identifiers

PMID: 29079675
DOI: 10.1101/gr.219956.116
PMCID: PMC5741049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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