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Article

SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.

The Journal of experimental medicine - 12 Jun 2006

Cannons Jennifer L, Yu Li J, Jankovic Dragana, Crotty Shane, Horai Reiko, Kirby Martha, Anderson Stacie, Cheever Allen W, Sher Alan, Schwartzberg Pamela L

Abstract excerpt

X-linked lymphoproliferative disease is caused by mutations affecting SH2D1A/SAP, an adaptor that recruits Fyn to signal lymphocyte activation molecule (SLAM)-related receptors. After infection, SLAM-associated protein (SAP)-/- mice show increased T cell activation and impaired humoral responses. Although SAP-/- mice can respond to T-independent immunization, we find impaired primary and secondary T-dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16754717
DOI: 10.1084/jem.20052097
PMCID: PMC2118305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.PMID 16754717Read ↗

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Ly9 (CD229)-Deficient Mice Exhibit T Cell Defects yet Do Not Share Several Phenotypic Characteristics Associated with SLAM- and SAP-Deficient MiceSemantic proximity Read ↗

X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses.Semantic proximity Read ↗

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