Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SH2D1A regulates T-dependent humoral autoimmunity.

The Journal of experimental medicine - 19 Jul 2004

Hron Jonathan D, Caplan Liron, Gerth Andrea J, Schwartzberg Pamela L, Peng Stanford L

Abstract excerpt

The signaling lymphocytic activation molecule (SLAM)/CD150 family includes a family of chromosome 1-encoded cell surface molecules with costimulatory functions mediated in part by the adaptor protein SH2D1A (SLAM-associated protein, SAP). Deficiency in SH2D1A protects mice from an experimental model of lupus, including the development of hypergammaglobulinemia, autoantibodies including anti-double stranded DNA,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Formation
Share to Antigens, CD
Share to Autoimmune Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Glycoproteins

Share to Immunoglobulins

Share to Receptors, Cell Surface

Share to Signaling Lymphocytic Activation Molecule Associated Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 15263031
DOI: 10.1084/jem.20040526
PMCID: PMC2212015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SH2D1A regulates T-dependent humoral autoimmunity.PMID 15263031Read ↗

SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.Semantic proximity Read ↗

SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase.Semantic proximity Read ↗

SLAM-SAP signaling promotes differentiation of IL-17-producing T cells and progression of experimental autoimmune encephalomyelitis.Semantic proximity Read ↗

Regulation of Cellular and Humoral Immune Responses by the SLAM and SAP Families of MoleculesSemantic proximity Read ↗

X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses.Semantic proximity Read ↗

SLAM family receptors and SAP adaptors in immunity.Semantic proximity Read ↗

XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP.Semantic proximity Read ↗

Reduced function of the adaptor SH2B3 promotes T1D via altered gc cytokine-regulated, T cell intrinsic immune toleranceSemantic proximity Read ↗

Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.Semantic proximity Read ↗

SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.Semantic proximity Read ↗

X-linked lymphoproliferative syndromes and related autosomal recessive disorders.Semantic proximity Read ↗

Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.