Detection of mutations associated with zidovudine resistance in human immunodeficiency virus by use of the polymerase chain reaction.

doi:10.1093/infdis/164.6.1075

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Article

Detection of mutations associated with zidovudine resistance in human immunodeficiency virus by use of the polymerase chain reaction.

The Journal of infectious diseases - 1 Dec 1991

Richman D D, Guatelli J C, Grimes J, Tsiatis A, Gingeras T

Abstract excerpt

A sensitive and specific polymerase chain reaction (PCR)-based assay was developed for four mutations in the reverse transcriptase gene of human immunodeficiency virus type 1 that have been associated with zidovudine resistance. These mutations were correlated in 366 specimens with zidovudine chemotherapy and resistance. Mutations at these four codons were detected only after zidovudine therapy. The usual...

Topics

Acquired Immunodeficiency Syndrome
Base Sequence
Codon
DNA, Viral
Drug Resistance, Microbial
Genotype
HIV Infections
HIV Reverse Transcriptase
HIV-1
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acid Hybridization

Oligonucleotide Probes

Phenotype

Polymerase Chain Reaction

Predictive Value of Tests

Probability

Source

Open in PubMed

Identifiers

PMID: 1720152
DOI: 10.1093/infdis/164.6.1075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1720152-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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