Article
Characterization of HIV isolates arising after prolonged zidovudine therapy.
Journal of acquired immune deficiency syndromes - 1 Jan 1992
Mayers D L, McCutchan F E, Sanders-Buell E E, Merritt L I, Dilworth S, Fowler A K, Marks C A, Ruiz N M, Richman D D, Roberts C R
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) was isolated from five patients with late-stage disease treated with zidovudine (ZDV) for more than 1 year. Peripheral blood mononuclear cells (PBMCs) were used for all virus isolations and to assay for drug resistance. The isolates exhibited a 10- to 1...
Topics
- Amino Acid Sequence
- Base Sequence
- Cells, Cultured
- DNA, Viral
- Drug Resistance, Microbial
- Genetic Variation
- Genotype
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Monocytes
- Phenotype
- RNA-Directed DNA Polymerase
- Sequence Homology, Nucleic Acid
- Zidovudine